Advances in Pre-Clinical and Clinical Research

Volume: 2

  • Open Access
  • Review Article

Augmented Reality in Healthcare: Unveiling Its Potential, Addressing Its Challenges, and Charting Its Future

Ranjitha H 1 *

1 Scientific Division, Ascentia Innovations, India

Year: 2025, Page: 1-10,

Received: June 13, 2025 Accepted: Sept. 10, 2025 Published: Sept. 29, 2025

Abstract

Augmented Reality (AR) is rapidly transforming the healthcare sector by seamlessly overlaying digital information on the real world, significantly enhancing various medical domains. Augmented reality technology improves our understanding of the real world by adding new sensory experiences to what we see, touch, and hear in our surroundings. This review explores diverse applications of AR, including its revolutionary impact on med- ical training and education through 3D anatomical visualization and surgical simulation as well as its role in sur- gical assistance and navigation for increased precision. A keyway to experience AR is through Head-Mounted Displays (HMDs), such as Google Glass, Smart Glass, and Microsoft HoloLens, which allow users to view and interact with virtual elements that are integrated into their real-world view. The use of augmented reality in med- icine has far-reaching implications, offering the potential to revolutionize patient care, diagnosis, and treatment. A thorough examination of existing research reveals numerous areas within the healthcare sector where AR can be effectively integrated. This article details the contributions of AR to diagnostics and imaging, remote collaboration in telemedicine, engagement in rehabilitation programs, and advancements in pharmaceutical research, along with critical challenges, including high implementation costs, technical limitations, data privacy concerns, and regula- tory hurdles. Despite these obstacles, this review highlights the recent developments in AR adoption and its ad- vantages in healthcare.

Keywords: Augmented reality; Virtual reality; Head-mounted displays; Visualization; Real-world

 

References

1. Farronato M, Maspero C, Lanteri V, Fama A, Ferrati F, Pettenuzzo A, et al. Current state of the art in the use of augmented reality in dentistry: a systematic review of the literature. BMC Oral Health. 2019;19(1):135.  

2. Dickey RM, Srikishen N, Lipshultz LI, Spiess PE, Carrion RE, Hakky TS. Augmented reality assisted surgery: a urologic training tool. Asian journal of andrology. 2016;18(5):732-4.

3. Khor WS, Baker B, Amin K, Chan A, Patel K, Wong J. Augmented and virtual reality in surgery-the digital surgical environment: applications, limitations and legal pitfalls. Annals of translational medicine. 2016;4(23):454.

4. Zhu E, Lilienthal A, Shluzas LA, Masiello I, Zary N. Design of Mobile Augmented Reality in Health Care Education: A Theory-Driven Framework. JMIR medical education. 2015;1(2):e10-e.

5. Amin D, Govilkar S. Comparative Study of Augmented Reality Sdk's. International Journal on Computational Science and Applications. 2015;5(1):11-26.

6. Dennler C, Bauer DE, Scheibler A-G, Spirig J, Götschi T, Fürnstahl P, et al. Augmented reality in the operating room: a clinical feasibility study. BMC Musculoskelet Disord. 2021;22(1):451.

7. Mendoza-Ramírez CE, Tudon-Martinez JC, Félix-Herrán LC, Lozoya-Santos JdJ, Vargas-Martínez A. Augmented Reality: Survey. Applied sciences. 2023;13(18):10491.

8. Blomqvist S, Seipel S, Engström M. Using augmented reality technology for balance training in the older adults: a feasibility pilot study. BMC Geriatr. 2021;21(1):144.

9. Hu M-H, Chiang C-C, Wang M-L, Wu N-Y, Lee P-Y. Clinical feasibility of the augmented reality computer-assisted spine surgery system for percutaneous vertebroplasty. Eur Spine J. 2020;29(7):1590-6.

10. Zhuang Y, Sun J, Liu J. Diagnosis of Chronic Kidney Disease by Three-Dimensional Contrast-Enhanced Ultrasound Combined with Augmented Reality Medical Technology. J Healthc Eng. 2021:5542822.

11. Tang KS, Cheng DL, Mi E, Greenberg PB. Augmented reality in medical education: a systematic review. Can Med Educ J. 2020;11(1):e81-e96.

12. Juanes-Méndez JA, Marcos-Pablos S, Velasco-Marcos MA, Izard SG. Medical Learning Through Simulations With Immersive Virtual Reality and Augmented Reality Devices. In: Marcos-Pablos S, Juanes-Méndez JA, editors. Technological Adoption and Trends in Health Sciences Teaching, Learning, and Practice. Hershey, PA, USA: IGI Global; 2022. p. 265-82.

13. Eckert M, Volmerg JS, Friedrich CM. Augmented Reality in Medicine: Systematic and Bibliographic Review. JMIR Mhealth Uhealth. 2019;7(4):e10967.

14. Baashar Y, Alkawsi G, Ahmad WNW, Alhussian H, Alwadain A, Capretz LF, et al. Effectiveness of Using Augmented Reality for Training in the Medical Professions: Meta-analysis. JMIR serious games. 2022;10(3):e32715-e.

15. Lee LN, Kim MJ, Hwang WJ. Potential of Augmented Reality and Virtual Reality Technologies to Promote Wellbeing in Older Adults. Applied Sciences. 2019;9(17):3556.

16. Yeung AWK, Tosevska A, Klager E, Eibensteiner F, Laxar D, Stoyanov J, et al. Virtual and Augmented Reality Applications in Medicine: Analysis of the Scientific Literature. J Med Internet Res. 2021;23(2):e25499-e.

17. O’Connor S, Andrews T. Mobile Technology and Its Use in Clinical Nursing Education: A Literature Review. J Nurs Educ. 2015;54(3):137-44.

18. Risling T. Educating the nurses of 2025: Technology trends of the next decade. Nurse Educ Pract. 2017;22:89-92.

19. Shachar M, Neumann Y. Differences Between Traditional and Distance Education Academic Performances: A Meta-Analytic Approach. The International Review of Research in Open and Distributed Learning. 2003;4(2).

20. Choules AP. The use of elearning in medical education: a review of the current situation. Postgrad Med J. 2007;83(978):212-6.

21. Car J, Carlstedt-Duke J, Tudor Car L, Posadzki P, Whiting P, Zary N, et al. Digital Education in Health Professions: The Need for Overarching Evidence Synthesis. J Med Internet Res. 2019;21(2):e12913-e.

22. Curran V, Matthews L, Fleet L, Simmons K, Gustafson DL, Wetsch L. A Review of Digital, Social, and Mobile Technologies in Health Professional Education. J Contin Educ Health Prof. 2017;37(3):195-206.

23. Iqbal AI, Aamir A, Hammad A, Hafsa H, Basit A, Oduoye MO, et al. Immersive Technologies in Healthcare: An In-Depth Exploration of Virtual Reality and Augmented Reality in Enhancing Patient Care, Medical Education, and Training Paradigms. Journal of Primary Care and Community Health. 2024;15:21501319241293311.

24. Song D, Lee JG. Chapter 5 - AI engineering in the Metaverse for human learning and performance. In: Nam CS, Song D, Jeong H, editors. Human-Centered Metaverse: Morgan Kaufmann; 2025. p. 75-87.

25. Bui DT, Barnett T, Hoang H, Chinthammit W. Usability of Augmented Reality Technology in Situational Telementorship for Managing Clinical Scenarios: Quasi-Experimental Study. JMIR Medical Education. 2023;9:e47228.

26. Palestini C, Basso A. The Photogrammetric Survey Methodologies Applied to Low Cost 3D Virtual Exploration in Multidisciplinary Field International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences. 2017;XLII-2/W8:195-202.

27. Cartucho J, Shapira D, Ashrafian H, Giannarou S. Multimodal mixed reality visualisation for intraoperative surgical guidance. Int J Comput Assist Radiol Surg. 2020;15(5):819-26.

28. Zafar S, Zachar JJ. Evaluation of HoloHuman augmented reality application as a novel educational tool in dentistry. Eur J Dent Educ. 2020;24(2):259-65.

29. Hanna MG, Ahmed I, Nine J, Prajapati S, Pantanowitz L. Augmented Reality Technology Using Microsoft HoloLens in Anatomic Pathology. Arch Pathol Lab Med. 2018;142(5):638-44.

30. Sutherland J, Belec J, Sheikh A, Chepelev L, Althobaity W, Chow BJW, et al. Applying Modern Virtual and Augmented Reality Technologies to Medical Images and Models. J Digit Imaging. 2019;32(1):38-53.

31. Moro C, Phelps C, Redmond P, Stromberga Z. HoloLens and mobile augmented reality in medical and health science education: A randomised controlled trial. British Journal of Educational Technology. 2020;52(2):680-94.

32. Gore H, Chaskar U, Borotikar B, Bhole K, editors. Medical Image Visualization using Augmented Reality. 2024 2nd DMIHER International Conference on Artificial Intelligence in Healthcare, Education and Industry (IDICAIEI); 2024.

33. Vyas V, Sharma A, Goyal S, Kothari N. Infrared vein visualization devices for ease of intravenous access in children: hope versus hype. Anestezjologia Intensywna Terapia. 2021;23(1):69-78.

34. Sakakibara J, Nasu K, Ikeda JI, Suzuki TH, Yokomizo J, Fujimoto H, et al. Clinical application of vein visualization apparatus AccuVein((R))500 in breast cancer surgery: a case report. J Med Case Reports. 2025;19(1):231.

35. Chen P-HC, Gadepalli K, MacDonald R, Liu Y, Kadowaki S, Nagpal K, et al. An augmented reality microscope with real-time artificial intelligence integration for cancer diagnosis. Nat Med. 2019;25(9):1453-7.

36. Douglas D, Wilke C, Gibson J, Boone J, Wintermark M. Augmented Reality: Advances in Diagnostic Imaging. Multimodal Technologies and Interaction. 2017;1(4):29.

37. Pereira-Azevedo NM, Venderbos LDF. eHealth and mHealth in prostate cancer detection and active surveillance. Translational andrology and urology. 2018;7(1):170-81.

38. Hemanth JD, Kose U, Deperlioglu O, de Albuquerque VHC. An augmented reality-supported mobile application for diagnosis of heart diseases. The Journal of Supercomputing. 2018;76(2):1242-67.

39. Al-Naser Y, Halka F, Alshadeedi F, Albahhar M, Athreya S. The applications of augmented reality in image-guided tumor ablations: A scoping review. Journal of Medical Imaging and Radiation Sciences. 2024;55(1):125-33.

40. Xiao SX, Wu WT, Yu TC, Chen IH, Yeh KT. Augmenting Reality in Spinal Surgery: A Narrative Review of Augmented Reality Applications in Pedicle Screw Instrumentation. Medicina. 2024;60(9):1485.

41. Lastrucci A, Wandael Y, Barra A, Ricci R, Maccioni G, Pirrera A, et al. Exploring Augmented Reality Integration in Diagnostic Imaging: Myth or Reality? Diagnostics 2024;14(13):1333.

42. Hey G, Guyot M, Carter A, Lucke-Wold B. Augmented Reality in Neurosurgery: A New Paradigm for Training. Medicina (Kaunas). 2023;59(10).

43. Jud L, Fotouhi J, Andronic O, Aichmair A, Osgood G, Navab N, et al. Applicability of augmented reality in orthopedic surgery - A systematic review. BMC Musculoskelet Disord. 2020;21(1):103.

44. Casari FA, Navab N, Hruby LA, Kriechling P, Nakamura R, Tori R, et al. Augmented Reality in Orthopedic Surgery Is Emerging from Proof of Concept Towards Clinical Studies: a Literature Review Explaining the Technology and Current State of the Art. Curr Rev Musculoskelet Med. 2021;14(2):192-203.

45. Sakai D, Joyce K, Sugimoto M, Horikita N, Hiyama A, Sato M, et al. Augmented, virtual and mixed reality in spinal surgery: A real-world experience. Journal of Orthopaedic Surgery. 2020;28(3):1-12.

46. Longo UG, De Salvatore S, Candela V, Zollo G, Calabrese G, Fioravanti S, et al. Augmented Reality, Virtual Reality and Artificial Intelligence in Orthopedic Surgery: A Systematic Review. Applied Sciences. 2021;11(7):3253.

47. Barcali E, Iadanza E, Manetti L, Francia P, Nardi C, Bocchi L. Augmented Reality in Surgery: A Scoping Review. Applied Sciences. 2022;12(14):6890.

48. Hou Y, Ma L, Zhu R, Chen X, Zhang J. A Low-Cost iPhone-Assisted Augmented Reality Solution for the Localization of Intracranial Lesions. PLoS One. 2016;11(7):e0159185-e.

49. Schlueter-Brust K, Henckel J, Katinakis F, Buken C, Opt-Eynde J, Pofahl T, et al. Augmented-Reality-Assisted K-Wire Placement for Glenoid Component Positioning in Reversed Shoulder Arthroplasty: A Proof-of-Concept Study. Journal of personalized medicine. 2021;11(8):777.

50. Teoli D, Aeddula NR. Telemedicine.  StatPearls. Treasure Island (FL) 2025.

51. Bui DT, Barnett T, Hoang HT, Chinthammit W. Tele-mentoring using augmented reality technology in healthcare: A systematic review. Australasian Journal of Educational Technology. 2021;37(4):68-88.

52. Naqvi WM, Naqvi IW, Mishra GV, Vardhan VD. The future of telerehabilitation: embracing virtual reality and augmented reality innovations. Pan Afr Med J. 2024;47:157.

53. Balloufaud M, Boujut A, Marie R, Guinaldo A, Fourcade L, Hamonet-Torny J, et al. Augmented Reality Exergames for Upcoming Cognitive-Motor Rehabilitation: User-Centered Design Approach and User Experience of Healthy Children. JMIR Rehabilitation and Assistive Technologies. 2025;12:e69205.

54. Khokale R, G SM, Ahmed S, Maheen S, Fawad M, Bandaru P, et al. Virtual and Augmented Reality in Post-stroke Rehabilitation: A Narrative Review. Cureus. 2023;15(4):e37559.

55. Condino S, Turini G, Viglialoro R, Gesi M, Ferrari V. Wearable Augmented Reality Application for Shoulder Rehabilitation. Electronics. 2019;8(10):1178.

56. Lamichhane P, Sukralia S, Alam B, Shaikh S, Farrukh S, Ali S, et al. Augmented reality-based training versus standard training in improvement of balance, mobility and fall risk: a systematic review and meta-analysis. Annals of Medicine and surgery. 2023;85(8):4026-32.

57. Ku J, Kim YJ, Cho S, Lim T, Lee HS, Kang YJ. Three-Dimensional Augmented Reality System for Balance and Mobility Rehabilitation in the Elderly: A Randomized Controlled Trial. Cyberpsychology, Behaviour, and Social Networking. 2019;22(2):132-41.

58. Kircik L, Goldust M. The Role of Virtual and Augmented Reality in Advancing Drug Discovery in Dermatology. J Cosmet Dermatol. 2025;24(2):e70071.

59. Turhan B, Gumus ZH. A Brave New World: Virtual Reality and Augmented Reality in Systems Biology. Frontiers in Bioinformatics. 2022;2.

60. Adapa K, Jain S, Kanwar R, Zaman T, Taneja T, Walker J, et al. Augmented reality in patient education and health literacy: a scoping review protocol. BMJ Open. 2020;10(9):e038416.

61. Ara J, Karim FB, Alsubaie MSA, Bhuiyan YA, Bhuiyan MI, Bhyan SB, et al. Comprehensive Analysis of Augmented Reality Technology in Modern Healthcare System. International Journal of Advanced Computer Science and Applications. 2021;12(6):840-9.

62. Makarov A. MobiDev. 2025.

63. Augmented Reality (AR) in Healthcare: Shaping the Future of Medical Technology - Digital Health Canada. 2024.

64. Bansal G, Rajgopal K, Chamola V, Xiong Z, Niyato D. Healthcare in Metaverse: A Survey on Current Metaverse Applications in Healthcare. IEEE Access. 2022;10:119914-46.

65. Augmented Reality And Virtual Reality In Healthcare Market To Reach $11.3Bn By 2030. 2024.

66. Global AR in Healthcare Market Size, Top Share, Trends, Report to 2032. Straits Research.

 

Cite this article

Ranjitha H. Augmented Reality in Healthcare: Unveiling Its Potential, Addressing Its Challenges, and Charting Its Future. Advances in Preclinical and Clinical Research. 2025; 6:202506.

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